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Scientists uncover hidden protein blocking cancer immunotherapy success

A joint UK-Finland project has revealed why immunotherapy often fails: cancers release a secreted protein called sClever-1, which systematically shuts down T cells. Researchers at the University of Turku and University of Birmingham found high blood levels of sClever-1 may predict resistance to treatment. Crucially, their investigational antibody, bexmarilimab, directly blocks this protein, potentially restoring effectiveness in hard-to-treat cancers. Published in Theranostics, the study could lead to smarter, personalised combination therapies for patients with advanced disease.

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Lab Innovations has fast become the UK’s must-attend event for the entire laboratory industry. Supported by some of the UK’s top science institutions, it is a key event for powering the business of science. The show floor is bursting with innovations from more than 160 leading scientific suppliers and manufacturers showcasing the latest laboratory developments and equipment. Exhibitors present the most cutting-edge technology applicable to a plethora of industries including life sciences, pharmaceuticals, academia, healthcare, chemical, food & drink, cleanroom and more.

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